Information on Loughborough
New advance announced in reducing 'bad' cholesterol
Posted on 09/12/2011
University of Leicester
Scientists from the University of Leicester and University of California Los Angeles (UCLA) have announced a breakthrough advance in tackling dangerous ‘bad’ cholesterol in the body.
They have filed two patents for developing targeted drugs that would act as a catalyst for lowering levels of ‘bad’ cholesterol.
Two research papers published by the academics enhance the understanding of the regulation of low-density lipoprotein (LDL) or “bad” cholesterol.
LDL, the so-called “bad” cholesterol, is often linked to medical problems like heart disease, stroke and clogged arteries.
In the body, cells in the liver produce an LDL receptor that binds LDL and removes it from the blood, thereby lowering cholesterol levels.
However, the LDL receptors can be hindered from their mission.
The scientists found that an enzyme called IDOL has been shown to play a key and specific role in the ability of the LDL receptor to bind with ‘bad’ cholesterol. Therefore targeting the enzyme with drugs would assist the LDL receptors in lowering circulating cholesterol in humans.
Professor John Schwabe, Head of Biochemistry at the University of Leicester, said: “Development of a drug that interferes with IDOL’s activity could help lower levels of LDL. Our research has greatly enhanced our understanding of this important process.”
Prof John Schwabe, Dr Ben Goult and Dr Louise Fairall at the University of Leicester in collaboration with the University of California Los Angeles (UCLA) published their research in Genes & Development and the Proceeds of the National Academy of Science (PNAS) . The research in the UK was funded by the Wellcome Trust and in the US by NIH and the National Heart Foundation of Australia Overseas Fellowship.
The study in Genes & Development announced the first atomic structural information on IDOL and identified the E2 ligase, UBE2D that works with IDOL to degrade the LDL receptor.
In the second research article published in PNAS, the team elucidated the molecular basis for the stringent specificity of IDOL for the LDL receptor.
Professor Schwabe added: “Remarkably, IDOL only targets three proteins for degradation (all lipoprotein receptors) and this research paper greatly enhances our understanding of this specificity and identifies key residues involved in mediating this interaction.
“A potential future drug that targets IDOL could be prescribed in conjunction with statin drugs, which also cut cholesterol levels by increasing production of the LDL receptor and these two studies make considerable headway towards this. “
The universities have filed 2 patents related to the research findings.
Both research papers are available online at:
Full PDF versions of the papers can be accessed for free through the website.
Pictured: Illustration of how the enzyme IDOL binds with LDL receptors, degrading them and hampering their ability to bind with ‘bad’ cholesterol.
Latest Loughborough News
Borough council steps in to support parish
Created: Monday 24th of November 2014 11:11:58 AM
Charnwood Borough Council is supporting a parish council which is unable to function because of a low number of councillors. Following a series of resignations, East Goscote Parish Council has three councillors and seven vacancies. It needs a minimum of four councillors to make decisions and conduct its ongoing business. ...
Read More: Borough council steps in to support parish
Loughborough highly commended at tourism awards
Created: Monday 24th of November 2014 10:11:36 AM
The Loughborough museum, run in partnership by Charnwood Borough Council and Leicestershire County Council, was Highly Commended at the 2014 Leicester and Leicestershire Excellence in Tourism Awards on November, 20, 2014....
Loughborough Alcohol Ban
Created: Monday 24th of November 2014 10:11:02 AM
International Supermarket, in Sparrow Hill, Loughborough, has had its licence to sell alcohol removed by CBC after a hearing of the Council s Licensing Sub-Committee....
Read More: Loughborough Alcohol Ban
Loughborough University Fuel Cell
Created: Saturday 22nd of November 2014 03:11:36 PM
Intelligent Energy Holdings plc the energy technology group founded on Loughborough University research has just announced the UK retail launch of Upp , the portable power solution driven by a hydrogen fuel cell to power up USB compatible devices....
Read More: Loughborough University Fuel Cell
Landlords invited to learn more about accreditation scheme
Created: Saturday 22nd of November 2014 10:11:32 AM
A roadshow to encourage private landlords in the borough to join an accreditation scheme will be held in Thurmaston....
Related Loughborough News
Unexpected discovery opens up new opportunities for targetting cancer
Created: Wednesday 11th of January 2012 04:01:57 PM
University of Leicester scientists announce a major advance in understanding the regulation of an important cancer target in Nature paper...
Leicester leads on heart attack genetic link discovery
Created: Monday 7th of March 2011 10:03:04 AM
University of Leicester Professor highlights potential for new treatments in 13 new genes associated with heart disease risk...
Scientists discover new mechanism for controlling blood sugar level
Created: Monday 29th of November 2010 02:11:02 PM
Advance in understanding of insulin secretion could impact on diabetes control involves University of Leicester...
Discovery of blood pressure genes could help prevent cardiovascular disease
Created: Monday 12th of September 2011 12:09:12 PM
Measurements can predict hypertension and cardiovascular disease in study co-led by University of Leicester researchers...
Fatal blood clot genetic risk breakthrough announced
Created: Thursday 25th of November 2010 01:11:11 PM
Researchers from Leicester and Cambridge lead discovery of genetic markers that identify people at risk of clot formation and heart attack ...
Most Read Loughborough News (today)
Mini moto campaign in Loughborough is a crushing success.
Created: Wednesday 2nd of July 2008 03:31:00 PM
14 motorbikes and mini-motos have been crushed after they were confiscated by police in Loughborough during a crack down on young people who drive dangerously and inconsiderately on roads, parks and public places....
Social media 'not to blame' for inciting rioters
Created: Friday 9th of December 2011 03:12:57 PM
University of Leicester researchers are involved in a study of the use of Twitter during the August riots...
Billion euro ESA mission to explore icy worlds of Jupiter
Created: Thursday 3rd of May 2012 04:05:46 PM
University of Leicester scientists involved in new European space exploration mission to the solar system's largest planet...
The Art of Jackson Pollock
Created: Wednesday 6th of June 2007 12:00:00 AM
Charnwood Museum in Loughborough and ArtSpace are offering visitors the chance to explore their own creative talents and produce their own ...
Read More: The Art of Jackson Pollock
Created: Tuesday 29th of April 2008 09:03:00 AM
Ladybirds ( or ladybugs if you are American) are loved by the public but now help is needed to monitor local numbers as an invasive species called the harlequin ladybird spreads across England....
Read More: Ladybird Survey